PoN-S : a systematic approach for applying the Physics of Notation (PoN)

Visual Modeling Languages (VMLs) are important instruments of communication between modelers and stakeholders. Thus, it is important to provide guidelines for designing VMLs. The most widespread approach for analyzing and designing concrete syntaxes for VMLs is the so-called Physics of Notation (PoN). PoN has been successfully applied in the analysis of several VMLs. However, despite its popularity, the application of PoN principles for designing VMLs has been limited. This paper presents a systematic approach for applying PoN in the design of the concrete syntax of VMLs. We propose here a design process establishing activities to be performed, their connection to PoN principles, as well as criteria for grouping PoN principles that guide this process. Moreover, we present a case study in which a visual notation for representing Ontology Pattern Languages is designed

ATP-dependent chromatin remodeling shapes the DNA replication landscape.

The eukaryotic DNA replication machinery must traverse every nucleosome in the genome during S phase. As nucleosomes are generally inhibitory to DNA-dependent processes, chromatin structure must undergo extensive reorganization to facilitate DNA synthesis. However, the identity of chromatin-remodeling factors involved in replication and how they affect DNA synthesis is largely unknown. Here we show that two highly conserved ATP-dependent chromatin-remodeling complexes in Saccharomyces cerevisiae, Isw2 and Ino80, function in parallel to promote replication fork progression. As a result, Isw2 and Ino80 have especially important roles for replication of late-replicating regions during periods of replication stress. Both Isw2 and Ino80 complexes are enriched at sites of replication, suggesting that these complexes act directly to promote fork progression. These findings identify ATP-dependent chromatin-remodeling complexes that promote DNA replication and define a specific stage of replication that requires remodeling for normal function

Towards a reference ontology on mulsemedia systems

EuropeanUnion’sHorizon2020 ResearchandInnovationprogramm

Towards a reference ontology for digital platforms

Digital platforms can be categorized into different types including ‘multi-sided platform’, ‘digital marketplace’, ‘crowdfunding platform’, ‘sharing economy platform’ and ‘on-demand platform’. As there is a lack of knowledge regarding the requirements and design of these digital platform types, we developed a method to design a digital platform reference ontology based on a taxonomy. The taxonomy provides an overview of digital platform properties, with the property values expressing the possible variations between digital platforms depending on their type. For each property value, we can create a digital platform reference ontology module using the five-step approach proposed by Ruy et al. [1] based on the patterns of the Unified Foundational Ontology (UFO). UFO is a high-level ontology that provides us with basic concepts for objects, events, social elements and their types, relations and properties. These digital platform reference ontology modules can be combined as building blocks to compose our reference ontology for expressing the functionality for digital platforms of all types. We believe this reference ontology can be a step towards a better understanding of digital platform functionality, better communication between stakeholders and eventually may facilitate future research and development of digital platforms